Brief Communication Role of medial prefrontal cortex Narp in the extinction of morphine conditioned place preference

نویسندگان

  • Ashley M. Blouin
  • Sungho Han
  • Anne M. Pearce
  • KaiLun Cheng
  • JongAh J. Lee
  • Alexander W. Johnson
  • Chuansong Wang
  • Matthew J. During
  • Peter C. Holland
  • Yavin Shaham
  • Jay M. Baraban
  • Irving M. Reti
چکیده

Role of medial prefrontal cortex Narp in the extinction of morphine conditioned place preference Ashley M. Blouin, Sungho Han, Anne M. Pearce, KaiLun Cheng, JongAh J. Lee, Alexander W. Johnson, Chuansong Wang, Matthew J. During, Peter C. Holland, Yavin Shaham, Jay M. Baraban, and Irving M. Reti Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland, 21205, USA; Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, Maryland, 21218, USA; Department of Molecular Virology, Immunology and Molecular Genetics, Ohio State University, Columbus, Ohio, 43210, USA; Solomon Snyder Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, Maryland, 21205, USA; The National Institutes of Health, National Institute on Drug Abuse, Intramural Research Program (NIH/NIDA/IRP), Baltimore, Maryland, 21224, USA

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Role of medial prefrontal cortex Narp in the extinction of morphine conditioned place preference.

Narp knockout (KO) mice demonstrate an impaired extinction of morphine conditioned place preference (CPP). Because the medial prefrontal cortex (mPFC) has been implicated in extinction learning, we tested whether Narp cells in this region play a role in the extinction of morphine CPP. We found that intracranial injections of adenoassociated virus (AAV) expressing wild-type (WT) Narp into the mP...

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تاریخ انتشار 2013